Gólgazdag döntetlennel kezdődött a negyedik forduló!
| 2010-09-11 13:45 | Everton Pienaar 39 Cahill 90+1 Arteta 90+2 |
3:3 | Man United Fletcher 43 Vidic 47 Berbatov 66 |
| 2010-09-11 16:00 | Newcastle | 0:2 | Blackpool Adam 45 (11-es) Campbell 90 |
| 2010-09-11 16:00 | Man City Vieira 56 |
1:1 | Blackburn Kalinic 25 |
| 2010-09-11 16:00 | West Brom Brunt 41 |
1:1 | Tottenham Modric 27 |
| 2010-09-11 16:00 | Arsenal Koscielny 24 Chamakh 58 Song 78 Vela 83 |
4:1 | Bolton Elmander 44 |
| 2010-09-11 16:00 | Fulham Dembélé 49, 90+1 |
2:1 | Wolves van Damme 10 |
| 2010-09-11 16:00 | Wigan Athletic Alcaraz 87 |
1:1 | Sunderland Gyan 66 |
| 2010-09-11 16:00 | West Ham Brunt 41 |
1:3 | Chelsea Essien 2, 83 Kalou 17 |
| 2010-09-12 17:00 | Birmingham | 0:0 | Liverpool |
| 2010-09-13 21:00 | Stoke City Jones 80 Huth 90+3 |
2:1 | Aston Villa Downing 35 |