A Chelsea és a Blackpool gálázott a nyitányon!
| 2010-08-14 13:45 | Tottenham | 0:0 | Man City |
| 2010-08-14 16:00 | Sunderland Bent 24 (11-es) Carr 56 (öngól) |
2:2 | Birmingham Dann 77 Ridgwell 88 |
| 2010-08-14 16:00 | Bolton | 0:0 | Fulham |
| 2010-08-14 16:00 | Wigan Athletic | 0:4 | Blackpool Taylor-Fletcher 16 Harewood 38, 43 Baptiste 75 |
| 2010-08-14 16:00 | Aston Villa Downing 15 Petrov 40 Milner 66 |
3:0 | West Ham |
| 2010-08-14 16:00 | Wolves Jones 37 Fletcher 39 |
2:1 | Stoke City Faye 55 |
| 2010-08-14 16:00 | Blackburn Kalinic 14 |
1:0 | Everton |
| 2010-08-14 18:30 | Chelsea Malouda 6, 90 Drogba 45, 55, 68 Lampard 63 |
6:0 | West Brom |
| 2010-08-15 17:00 | Liverpool Ngog 46 |
1:1 | Arsenal Reina 90 (öngól) |
| 2010-08-16 21:00 | Man United Berbatov 33 Fletcher 41 Giggs 85 |
3:0 | Newcastle |